Table 1.

Changes in idiopathic epilepsy (IE) risk-associated allele frequency over time in dogs born between 1985 and1999 (older cohort) compared to dogs born between 2000 and 2015 (recent cohort) at both Canis familiaris chromosome (CFA) 14 and 37 loci.

	CFA14—BICF2S23230472			CFA37—BICF2P271491
	Risk-Allele A Frequency Older Cohort	Risk-Allele A Frequency Recent Cohort	p-Value	Risk-Allele G Frequency Older Cohort	Risk-Allele G Frequency Recent Cohort	p-Value
All dogs
Control	0.14 (n = 85)	0.15 (n = 66)	0.41	0.62 (n = 85)	0.73 (n = 66)	0.03
IE	0.25 (n = 16)	0.21 (n = 36)	0.41	0.91 (n = 16)	0.74 (n = 36)	0.04
Total	0.15 (n = 101)	0.17 (n = 102)	0.36	0.67 (n = 101)	0.74 (n = 102)	0.09
Unrelated dogs
Control	0.13 (n = 80)	0.14 (n = 52)	0.45	0.64 (n = 80)	0.72 (n = 52)	0.10
IE	0.23 (n = 15)	0.23 (n = 28)	0.60	0.90 (n = 15)	0.68 (n = 28)	0.02
Total	0.15 (n = 95)	0.18 (n = 80)	0.29	0.68 (n = 95)	0.71 (n = 80)	0.33