TABLE 2.
Days after bacterial challenge | No. of animals with positive NP colonization/total no. of animals challenged (%) in:
|
|
---|---|---|
Study A | Study B | |
1 | 7/7 (100) | 7/7 (100) |
2 | 7/7 (100) | 7/7 (100) |
4 | 7/7 (100) | 7/7 (100) |
6 | 5/6 (83) | 7/7 (100) |
8 | 5/8 (63) | 7/7 (100) |
16 | 1/6 (17) | ND |
23 | 0/6 (0) | ND |
Chinchillas (2 to 3 months old) were challenged intranasally with 108 CFU of NTHI 12 on day 0 as described in Materials and Methods. In study A, NP lavage was performed on each group only once. In study B, NP lavage was performed five times on the same group.
ND, not determined.