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. 2024 Jan 11;25(2):905. doi: 10.3390/ijms25020905

Figure 6.

Figure 6

Enrichment analysis for histone modifications. The dot plots showed the top twenty enrichment terms for histone modification associated with up DEGs (A) and down DEGs (B) in response to I-BRD9 treatment. The x-axis represents the gene ratio, and the y-axis describes the enrichment components. The area of the circle is proportional to the number of genes assigned to the term, and the color accords with the adjusted p-value. (C) The levels of histone marks, including H3K4me3, H3K27me3, H3K9Ac, and H3K18Ac, were examined via immunoblot analysis in HuLM cells in the presence (I-BRD9 (1–5 µM) or absence (DMSO) of I-BRD9. (D) The levels of H3K4me3 were quantified in HuLM cells in the presence or absence of I-BRD9 using NIH Image J.