Table 1.

Gene mutational profile at presentation (8/2018) and relapse (9/2019)

Gene	8/2018 Peripheral blood	2018 Mutation effect	2018 Mutation VAF (%)	9/2019 Ascitic fluid	2019 Mutation VAF (%)	2019 Mutation effect	Pathogenic
CD79B	c.586T > C p.Y196H	Missense	35	c.586T > C p.Y196H	43	Missense	Yes
MYD88	c.794T > C p.L265P	Missense	35	c.794T > C p.L265P	63	Missense	Yes
TBL1XR1	c.1337A > G p.Y446C	Missense	30	c.1337A > G p.Y446C	34	Missense	Yes
TBL1XR1	c.1192A > T p.K398a	Nonsense	34	c.1192A > T p.K398a	60	Nonsense	Yes
TP53	c.742C > T p.R248W	Missense	39	c.742C > T p.R248W	90	Missense	Yes
PIM1	c.373C > T p.P125S	Missense	51	c.373C > T p.P125S	64	Missense	Uncertain
PIM1			–	c.149G > A p.G50D	28	Missense	Uncertain
PIM1			–	c.97C > T p.P33S	29	Missense	Uncertain
ETV6	c.33 + 1G > A	Splice donor	53	–	0	–	Yes
BTK			–	c.1442G > C p.C481S	45	Missense	Yes
FOXO1			–	c.482G > A p.G161D	47	Missense	Yes
NF1			–	c.7064G > T p.S2355I	50	Missense	Uncertain
NOTCH1			–	c.2856C > A p.D952E	47	Missense	Uncertain
ABL2			–	c.2503G > T p.A835S	30	Missense	Uncertain
BRAF	c.1600G > A p.G534S	Missense	37	c.1600G > A p.G534S	41	Missense	Uncertain

(VAF) Variant allele frequency.