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. 2024 Jan 9;25(2):832. doi: 10.3390/ijms25020832

Figure 6.

Figure 6

Gabazine reduces the proportion of short colonic contractions in Nlgn3R451C mice. Representative spatiotemporal maps of WT and Nlgn3R451C colonic activity in (A) control conditions and (B) after administration of 10 µM gabazine to the organ bath. (C) Effect of gabazine on CMMC frequency in WT and Nlgn3R451C mice. No changes were observed for (D) resting colon diameter or (E) CMMC length. (F) The short contraction frequency was reduced in both WT and Nlgn3R451C colons; WT n = 18; Nlgn3R451C n = 14. Calibration bar: 10 mm, 200 s. One-way ANOVA Holm–Sidak multiple comparisons test. * p < 0.05, *** p < 0.001.