Table 2.
Regional small intestinal motility parameters from jejunum and ileum in wild-type and Nlgn3 R451C mice.
| Small Intestinal Motility Parameters | Jejunum | Ileum | |||||
|---|---|---|---|---|---|---|---|
| WT n = 17 |
Nlgn3R451C n = 16 |
Normality Passed? | WT n = 16 |
Nlgn3R451C n = 16 |
Normality Passed? | ||
| Resting diameter (mm) | Prox | 4.7 ± 0.1 | 4.2 ± 0.1 * | Yes. WT: w = 0.9, p = 0.3. Nlgn3R451C: w = 0.9, p = 0.1 |
3.4 ± 0.1 | 3.6 ± 0.1 | Yes. WT: w = 0.98, p = 0.96. Nlgn3R451C: w = 0.9, p = 0.07 |
| Mid | 4.7 ± 0.1 | 4.2 ± 0.1 * | Yes. WT: w = 0.9, p = 0.3. Nlgn3R451C: w = 0.96, p = 0.6 |
3.3 ± 0.1 | 3.4 ± 0.1 | Yes. WT: w = 0.98, p = 0.9. Nlgn3R451C: w = 0.9, p = 0.07 |
|
| Distal | 4.9 ± 0.1 | 4.3 ± 0.1 † | Yes. WT: w = 0.9, p = 0.4. Nlgn3R451C: w = 0.95, p = 0.5 |
3.2 ± 0.1 | 3.3 ± 0.1 | Yes. WT: w = 0.9, p = 0.2. Nlgn3R451C: w = 0.9, p = 0.1 |
|
| Constricted diameter (mm) | Prox | 3.9 ± 0.1 | 3.5 ± 0.1 | Yes. WT: w = 0.9, p = 0.3. Nlgn3R451C: w = 0.9, p = 0.1 |
2.7 ± 0.1 | 2.9 ± 0.1 | Yes. WT: w = 0.95, p = 0.6. Nlgn3R451C: w = 0.9, p = 0.06 |
| Mid | 3.7 ± 0.1 | 3.5 ± 0.1 | Yes. WT: w = 0.9, p = 0.3. Nlgn3R451C: w = 0.95, p = 0.5 |
2.5 ± 0.1 | 2.7 ± 0.1 | Yes. WT: w = 0.98, p = 0.9. Nlgn3R451C: w = 0.9, p = 0.2 |
|
| Distal | 4.0 ± 0.1 | 3.6 ± 0.1 * | Yes. WT: w = 0.98, p = 0.95. Nlgn3R451C: w = 0.9, p = 0.4 | 2.5 ± 0.1 | 2.7 ± 0.1 | Yes. WT: w = 0.9, p = 0.3. Nlgn3R451C: w = 0.9, p = 0.1 |
|
| Intra PCC frequency (sec−1) | Prox | CI: 0.5–0.7 | CI: 0.6–0.7 * | No. w = 0.95, p = 0.0002 | CI: 0.3–0.6 | CI: 0.4–0.5 | No. w = 0.91, p < 0.0001 |
| Mid | CI:0.5–0.7 | CI: 0.6–0.7 * | CI: 0.3–0.6 | CI: 0.4–0.6 | |||
| Distal | CI: 0.5–0.7 | CI: 0.5–0.6 * | CI: 0.4–0.6 | CI: 0.4–0.5 | |||
Mean ± SEM, genotype comparisons; confidence intervals (CI) * p < 0.05 † p < 0.01. Shapiro–Wilk normality test performed.