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. 2024 Jan 5;25(2):687. doi: 10.3390/ijms25020687

Figure 3.

Figure 3

Gene expression changes in WT and KO mice in the mPFC following a single injection of noribogaine (10 mg/kg or 40 mg/kg). (A) Males: Immediate early genes Npas4, Egr1, and cFos; glutamate receptor GRIA1 and GRIN2A; serotonin receptor Htr2a (5HT2AR). Two-way ANOVA–Tukey: * p < 0.05, ** p < 0.01, *** p < 0.001 difference from vehicle (KO injected with noribo vs. vehicle KO and WT injected with noribo vs. vehicle WT); # p < 0.05, ## p < 0.01, ### p < 0.001 difference from noribogaine (comparing low vs. high dose); $ p < 0.05 difference from vehicle (vehicle WT vs. vehicle KO). (B) Females: Immediate early genes Npas4, Egr1, and cFos; glutamate receptor GRIA1 and GRIN2A; serotonin receptor Htr2a. Two-way ANOVA–Tukey: * p < 0.05, ** p < 0.01, *** p < 0.001 difference from vehicle (KO injected with noribo vs. vehicle KO and WT injected with noribo vs. vehicle WT); # p < 0.05, ## p < 0.01, ### p < 0.001 difference from noribogaine (comparing low vs. high dose); $ p < 0.05 difference from vehicle (vehicle WT vs. vehicle KO).