Table 1.
Effects of systemic noribogaine administration (Noribo 40) on paired-pulse ratio and NMDA current density in mPFC pyramidal cells from male wildtype and 5HT2A knockout (KO) mice.
| Paired-Pulse Ratio (PPR) | INMDA (pA/pF) | NMDA/AMPA Ratio | ||||
|---|---|---|---|---|---|---|
| Wildtype | 5HT2A Knockout | Wildtype | 5HT2A Knockout | Wildtype | 5HT2A Knockout | |
| Vehicle | 1.03 ± 0.06 (13) | 1.19 ± 0.05 (7) | 6.02 ± 1.37 (11) | 2.35 ± 0.45 (11) ** | 0.75 ± 0.04 (10) | 0.55 ± 0.04 (10) && |
| Noribo 40 | 1.00 ± 0.08 (12) | 1.09 ± 0.07 (14) | 1.48 ± 0.56 (8) $ | 1.95 ± 0.22 (17) | 0.56 ± 0.03 (8) # | 0.60 ± 0.04 (10) |
No significant differences were observed comparing PPR values; one-way ANOVA, F(3,40) = 0.9, p = 0.4. One-way ANOVA showed significantly different NMDA current densities: F(3,42) = 7.6, p < 0.001. $ Mean INMDA current-density values in WT were significantly reduced by Noribo 40 (post-hoc Tukey test; q = 6.2, p < 0.01). ** Mean INMDA current-density values were significantly smaller in KO compared to WT (post-hoc Tukey test; q = 6.2, p < 0.01). # NMDA/AMPA ratios in WT were significantly reduced by Noribo 40, according to one-way ANOVA F(1,17) = 12.9, p = 0.002; post-hoc Tukey test; q = 5.1, p = 0.003. && NMDA/AMPA ratios in WT were significantly larger compared to KO; one-way ANOVA F(1,19) = 11.9, p = 0.003.