Table 2.
Top 10 downregulated miRNAs ≥ 10 UMI.
| hsa-miRNA | UMI | LFC | Adj-P | Validated HCC Target | Reference |
|---|---|---|---|---|---|
| miR-191-5p | 2691.1 | −0.569 | 1.3E−08 | EGR1/UBE2D3/ZO-1 | [45,46] |
| miR-26b-5p | 3497.3 | −0.566 | 1.7E−07 | SNAIL/MMP2/SMAD1/KPNA2/PIM-2 | [47,48,49,50] |
| miR-146a-5p | 6559.6 | −0.904 | 6.7E−16 | CFH/RAC1/ERBB4/IQGAP1/NRA5/PARK2/PTG52 | [51,52,53,54] |
| GAP1/TRAF6/SMAD4/BRCA1 | |||||
| miR-142-3p | 7768.9 | −1.274 | 9E−18 | LDHA/HMGB1/RAC1/ZEB1/CD133/SLC3A2 | [51,52,53,54] |
| miR-126-3p | 9528.3 | −0.608 | 1.3E−07 | LRP6/PIK3R2GAS5/SPRED1/ADAM9 | [55,56,57,58] |
| let-7i-5p | 9798.9 | −0.922 | 3.2E−15 | TSP1/CD47 | [59] |
| let-7f-5p | 13,136.2 | −1.236 | 1.2E−19 | No direct HCC reference | n/a |
| let-7a-5p | 13,460.6 | −1.155 | 9E−18 | MMP11/BZW2//STAT3/IAP3/HMGA2/IGFBP2/3 | [60,61,62,63,64] |
| let-7b-5p | 17,716.1 | −0.889 | 7.9E−08 | CDC25B/HMGA2/GPC3 | [65,66] |
| miR-16-5p | 57,609.4 | −0.543 | <0.001 | GF1R/ANXA11/IGF1R | [67,68,69,70,71] |