Table 1.
Percentage of GC samples belonging to the indicated molecular subtypes and organized based on TRIB genes expression. The quartile subdivision of gene expression in “high-25” and “other” was used. Cut-off ≥ 0.6 and <0.6 for TRIB1 and TRIB2; cut-off ≥ 0.7 and <0.7 for TRIB3. CIN = chromosomal instability, MSI = microsatellite instability, GS = genomically stable, EBV = Epstein–Barr virus tumors, POLE = POLE mutated tumors, ultra-mutated phenotype.
| Quartile | CIN (n = 223) | MSI (n = 73) | GS (n = 50) | EBV (n = 30) | POLE (n = 7) | |
|---|---|---|---|---|---|---|
| TRIB1 | High-25 | 49% | 32% | 24% | 37% | 57% |
| Others | 51% | 58% | 76% | 63% | 43% | |
| TRIB2 | High-25 | 5% | 36% | 4% | 23% | 0% |
| Others | 95% | 64% | 96% | 77% | 100% | |
| TRIB3 | High-25 | 43% | 23% | 4% | 10% | 43% |
| Others | 52% | 77% | 96% | 90% | 57% |