Table 2.
Inflammatory parameters for the different LPA genotype and haplotype subgroups.
| Parameter | Subgroup | p Value | ||
|---|---|---|---|---|
| rs10455872 | A/A (n = 40) | A/G (n = 25) | G/G (n = 5) | |
| IL-6 (ng/L) | 1.69 (1.20–2.44) | 2.07 (1.41–2.67) | 2.07 (1.41–2.67) | 0.328 |
| IL-8 (ngl/L) | 12.55 (10.43–17.30) | 14.60 (11.40–36.65) | 2.56 (0.83–5.59) | 0.383 |
| TNF-α (ng/L) | 3.91 (3.36–5.14) | 3.91 (3.21–16.12) | 4.56 (3.31–5.10) | 0.921 |
| VCAM-1 (ng/L) | 0.62(0.50–0.89) | 0.65 (0.54–0.93) | 0.52 (0.29–1.43) | 0.489 |
| rs3798220 | T/T (n = 48) | T/C (n = 21) | C/C (n = 1) | |
| IL-6 (ng/L) | 1.69 (1.17–2.67) | 1.66 (1.20–2.15) | 2.18 | 0.558 |
| IL-8 (ng/L) | 13.00 (10.50–17.48) | 16.30 (10.70–20.50) | 17.90 | 0.524 |
| TNF-α (ng/L) | 3.91 (3.13–5.57) | 4.46 (3.36–5.14) | 3.91 | 0.940 |
| VCAM-1 (ng/L) | 0.60 (0.51–0.86) | 0.78 (0.51–0.92) | 0.72 | 0.445 |
| Haplotype AT | no AT (n = 8) | one AT (n = 42) | two AT (n = 20) | |
| IL-6 (ng/L) | 1.90 (1.05–4.50) | 1.69 (1.20–2.67) | 1.45 (1.17–2.53) | 0.640 |
| IL-8 (ng/L) | 17.65 (6.90–34.80) | 14.60 (11.30–20.60) | 10.90 (10.18–15.48) | 0.281 |
| TNF-α (ng/L) | 4.56 (3.70–10.52) | 3.91 (3.36–5.14) | 3.91 (3.13–10.03) | 0.790 |
| VCAM-1 (ng/L) | 0.61 (0.40–0.97) | 0.78 (0.53–0.92) | 0.59 (0.47–0.64) | 0.087 |
| Haplotype AC | no AC (n = 48) | one AC (n = 21) | two AC (n = 1) | |
| IL-6 (ng/L) | 1.69 (1.17–2.67) | 1.66 (1.20–2.15) | 2.18 | 0.558 |
| IL-8 (ng/L) | 13.00 (10.50–17.48) | 16.30 (10.70–20.50) | 17.90 | 0.524 |
| TNF-α (ng/L) | 3.91 (3.13–5.57) | 4.46 (3.36–5.14) | 3.91 | 0.940 |
| VCAM-1 (ng/L) | 0.60 (0.51–0.86) | 0.78 (0.51–0.92) | 0.72 | 0.445 |
| Haplotype GT | no GT (n = 40) | one GT (n = 25) | two GT (n = 5) | |
| IL-6 (ng/L) | 1.69 (1.20–2.44) | 2.07 (1.41–2.67) | 2.56 (0.83–5.59) | 0.328 |
| IL-8 (ng/L) | 12.55 (10.43–17.30) | 14.60 (11.40–36.65) | 13.05 (3.30–19.95) | 0.383 |
| TNF-α (ng/L) | 3.91 (3.36–5.14) | 3.91 (3.21–16.12) | 4.56 (3.31–5.10) | 0.921 |
| VCAM-1 (ng/L) | 0.62 (0.50–0.89) | 0.65 (0.54–0.93) | 0.52 (0.29–1.43) | 0.489 |
Data are median (lower–upper quartiles) or mean values ± standard deviation except for C/C and two alleles of the AC haplotype, where only one subject was genotyped. p values for rs3798220 and the AC haplotype were obtained using Student’s t tests for variables shown as mean values ± standard deviation, and Mann–Whitney U tests for variables shown as median values (lower–upper quartiles). Other p values were obtained using one-way ANOVA for variables presented as mean values ± standard deviation, and Kruskal–Wallis test for variables shown as median values (lower–upper quartiles). IL, interleukin; TNF-α, tumor necrosis factor-α; VCAM-1, vascular cell adhesion molecule 1.