Table 3.
Hemostatic parameters for the different LPA genotype and haplotype subgroups.
| Parameter | Subgroup | p Value | ||
|---|---|---|---|---|
| rs10455872 | A/A (n = 40) | A/G (n = 25) | G/G (n = 4) | |
| D-dimer (µg/L) | 270.00 (190.00–550.00) | 268.00 (190.00–385.75) | 313.00 (203.75–429.00) | 0.786 |
| TAFI (%) | 102.00 (88.25–110.25) | 93.00 (86.50–110.25) | 93.50 (76.00–122.25) | 0.784 |
| OCP (Abs-sum) | 24.45 (20.03–29.60) | 23.10 (19.55–27.10) | 23.50 (16.80–24.60) | 0.715 |
| OHP (Abs-sum) | 6.50 (4.65–8.63) | 6.70 (4.70–8.60) | 6.00 (5.00–7.00) | 0.946 |
| OFP (%) | 72.00 ± 8.65 | 71.16 ± 8.18 | 68.67 ± 6.11 | 0.819 |
| rs3798220 | T/T (n = 48) | T/C (n = 20) | C/C (n = 1) | |
| D-dimer (µg/L) | 270.00 (190.00–421.00) | 295.00 (192.00–649.00) | 190.00 | 0.299 |
| TAFI (%) | 100.00 (85.00–111.00) | 100.00 (89.75–109.25) | 113.00 | 0.519 |
| OCP (Abs-sum) | 23.40 (19.60–27.80) | 24.05 (19.78–30.20) | 30.00 | 0.362 |
| OHP (Abs-sum) | 6.30 (4.70–8.30) | 7.40 (5.53–8.90) | 6.70 | 0.583 |
| OFP (%) | 71.68 ± 8.16 | 70.90 ± 8.95 | 78.00 | 0.615 |
| Haplotype AT | no AT (n = 6) | one AT (n = 43) | two AT (n = 20) | |
| D-dimer (µg/L) | 217.50 (190.00–397.00) | 279.00 (192.00–526.00) | 252.50 (190.00–484.50) | 0.460 |
| TAFI (%) | 99.00 (78.00–116.50) | 97.50 (88.25–109.75) | 102.00 (84.25–112.50) | 0.997 |
| OCP (Abs-sum) | 23.50 (19.35–31.05) | 23.40 (19.60–28.20) | 22.40 (20.20–27.73) | 0.932 |
| OHP (Abs-sum) | 6.50 (5.50–9.50) | 27.10 (4.70–8.70) | 5.60 (4.45–8.15) | 0.558 |
| OFP (%) | 70.80 ± 5.93 | 71.09 ± 8.63 | 72.70 ± 8.37 | 0.737 |
| Haplotype AC | no AC (n = 48) | one AC (n = 20) | two AC (n = 1) | |
| D-dimer (µg/L) | 270.00 (190.00–421.00) | 295.00 (192.00–649.00) | 190.00 | 0.299 |
| TAFI (%) | 100.00 (85.00–111.00) | 100.00 (89.75–109.25) | 113.00 | 0.519 |
| OCP (Abs-sum) | 23.40 (19.60–27.80) | 24.05 (19.78–30.20) | 30.00 | 0.362 |
| OHP (Abs-sum) | 6.30 (4.70–8.30) | 7.40 (5.53–8.90) | 6.70 | 0.583 |
| OFP (%) | 71.68 ± 8.16 | 70.90 ± 8.95 | 78.00 | 0.615 |
| Haplotype GT | no GT (n = 40) | one GT (n = 25) | two GT (n = 4) | |
| D-dimer (µg/L) | 270.00 (190.00–550.00) | 268.00 (190.00–385.75) | 313.00 (203.75–429.00) | 0.786 |
| TAFI (%) | 102.00 (88.25–110.25) | 93.00 (86.50–110.25) | 93.50(76.00–122.25) | 0.784 |
| OCP (Abs-sum) | 24.45 (20.03–29.60) | 23.10 (19.55–27.10) | 23.50 (16.80–27.40) | 0.715 |
| OHP (Abs-sum) | 6.50 (4.65–8.63) | 6.70 (4.70–8.60) | 6.00 (5.00–7.00) | 0.946 |
| OFP (%) | 72.00 ± 8.65 | 71.16 ± 8.18 | 68.67 ± 6.11 | 0.819 |
Data are median values (lower–upper quartiles) or mean values ± standard deviation except for C/C and two alleles of the AC haplotype, where only one subject was genotyped. p values for rs3798220 and the AC haplotype were obtained using Student’s t tests for variables shown as mean values ± standard deviation, and Mann–Whitney U tests for variables shown as median values (lower–upper quartiles). Other p values were obtained using one-way ANOVA for variables presented as mean values ± standard deviation, and Kruskal–Wallis test for variables shown as median values (lower–upper quartiles). TAFI, thrombin-activatable fibrinolysis inhibitor; OCP, overall coagulation potential; OHP, overall hemostatic potential; OFP, overall fibrinolytic potential.