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. 2024 Jan 8;25(2):787. doi: 10.3390/ijms25020787

Figure 1.

Figure 1

RRMS patients feature elevated NOx serum levels compared to somatic symptom disorder patients (Soma). (A–E) Violin plots with overlaying box plots comparing two groups. Boxes display the median as well as the 25th and 75th percentiles. The whiskers extend from the hinge to the largest and smallest values, respectively, but no further than 1.5 * IQR from the hinge. (F,G) Simple linear regression using either age or EDSS as independent and NOx serum as dependent variable. The area in-between the dotted lines shows the 95% confidence band. (H,I) Simple linear regression using NOx serum as independent and either QAlbumin or NOx CSF as dependent variable. The area in-between the dotted lines shows the 95% confidence band. (J) Pie charts comparing the percentage of patients with acute relapse and active lesions on cMRI at time of sampling between the high and low serum NOx group. CSF—Cerebrospinal fluid, EDSS—Expanded Disability Status Scale, IQR—Interquartile range, M—Months, MRI—Magnetic resonance imaging, MRZ—Antibody indices (AI) against measles, rubella, and varicella zoster virus. MRZ was defined ‘positive’ if at least two out of three AI were higher than 1.5, neg—Negative, NOx—Nitrosative stress molecules, ns—Not significant, OCBs—Oligoclonal bands, Q—CSF/serum ratio, RRMS—Relapsing–remitting Multiple Sclerosis, Soma—Somatic symptom disorder, *—multiplied by.