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. 2024 Jan 17;25(2):1152. doi: 10.3390/ijms25021152
Author Material BG Particle Size BG Incorporation
Chen et al. (2021) [41] n Ce-BG/GelMA n = 0, 2, 5 The mean particle size of the 0 Ce-BG, 2 Ce-BG, and 5 Ce-BG was 362.8 nm, 389.42 nm, and 208.9 nm, respectively Ce-BG powders were added at 1% w/v to a GelMA foam (10% w/v) and LAP (photoinitiator 0.1% w/v) solution. The solution was stirred for 1 h and they were cross-linked using 365 nm UV light for 20 s.
Hu et al. (2021) [43] SIS/MBG@Exos Mesoporous BG was used, no particle size mentioned MBG was added to a neutralized SIS solution and blended, and sodium alginate (SA) was then added as a thickener. The solution was centrifuged; this slurry was used in an extrusion cryogenic 3D printing system to fabricate the scaffolds.
Kong et al. (2018) [46] SA-BG-DFO-GDL 20.28 µm (90% < 34.86 µm) 0.02 g BG powders were added into 1 mL of SA solution (2 wt.%) with 0.01 g of GDL, followed by repeatedly pipetting in a syringe to generate homogeneous solution. Under the weak acid condition of GDL, both Ca and Si ions could be released from BG powders, and the released Ca ions contributed to the cross-linking of hydrogels.
Li et al. (2020) [48] PAB and PABC BG nanoparticles, no particle size mentioned A PEGDA/BGN/C solution was mixed with SA solution, and then I2959 was added as photoinitiator. The solution was cross-linked at 365 nm for 5 min.
Li et al. (2022) [49] SA/BG-MMP9-siNP 20 µm is the average particle size 2% w/v 45S5 BG and 2% w/v GDL powders were mixed with 1 mL of 2% SA solution. The resulting solution was homogenized and then placed into a mold for it to form the hydrogel.
Ma et al. (2020) [52] SA/BG-SA (CM)-PLGA(PFD). CM = conditioned medium; PFD = Poly(9,9-di-n-dodecylfluorene) Size ranges from 5 µm to 20 µm 1 mL of 2% (w/v) SA solution, 20 mg of BG powders, and 20 mg of GDL were manually mixed in an injector with a t-branch pipe to acquire a homogeneous solution. Then, the mixed solution was injected into a Teflon mold with a cylindrical shape. After 5 min, SA-2% BG hydrogels were obtained because the Ca2+ ions released from BG with the GDL presence caused the gelation of SA/BG.
Zhu et al. (2022) [56] HQBn, where n corresponds to the percentage of magnesium present in the BG, n = 0, 2, 5, 10 Particle diameter is around 200 nm HA-PBA and QCS were firstly dissolved in saline solution to obtain a precursor solution at a concentration of 2% (w/w). Then, QCS solution was added dropwise into HA-PBA solution according to the volume ratio of 1:1 under stirring, and gelation occurred within 1 min after mixing. The mixture was stirred for another 30 min to obtain a stable hydrogel (HQ). Similarly, HQB hydrogels were formed by mixing QCS
and the mixture of HA-PBA and BGs.
Chen et al. (2019) [40] Trilayer scaffold: chitosan/PVA/PVAnBG Diameter around 800 nm BG was incorporated by sequential electrospinning. Different ratios of nBG (5%, 10%, 20%, 40% wt.) were mixed with PVA and electrospun.
Gao et al. (2017) [42] CPB and CP scaffolds. CPB: collagen, PCL (polycaprolactone), and BG. CP: collagen and PCL Approximate size 100 nm 1:1:1 Col/PCL/BGNs blended solutions (4% w/w of each composition) were obtained by dissolving them in hexafluoroisopropanol (HFIP) under continuous stirring for 6 h. Nanofibrous scaffolds were obtained because of electrospinning this solution.
Jana et al. (2022) [44] F-1 (fish collagen + BG powders)—Fcol/BG microfibers
F-2 (fish collagen + Cu-doped BG powders)—Fcol/CuBG microfibers.
F-3 (fish collagen + Co-doped BG powders)—Fcol/CoBG microfibers
F-4 (fish collagen + Cu- and Co-doped BG powders)-Fcol/CuCoBG microfibers
Highly fine powders, size not specified Electrospinning of the collagen and bioactive glass to form a mat. 15% w/v collagen suspension was mixed with 15% BG powder/ion-doped, and then the solution was electrospun.
Jiang et al. (2020) [45] BG/PDA/PM Diameter between 80 nm and 130 nm The PDA-coated scaffolds were soaked in BG suspension solution (5% wt./v in Tris-HCl buffer) for 2 h at room temperature to allow for the loading of BG particles onto the scaffolds (BG/PDA/PM).
Li et al. (2017) [47] PEM: patterned electrospun membrane
BG/PEM
BG powders were used and sieved through a 300 mesh. Size not specified Dressing preparation and BG incorporation were performed via pulsed laser deposition technique (PLD). PEM was fixed in a PLD stainless-steel chamber and BG discs were used as the target, which was irradiated with a laser beam.
Sharaf et al. (2022) [54] BGNP CA
BGNP: bioactive glass nanoparticles; CA: cellulose acetate
Nanoparticles, size not specified The electrospun fibers contained the BG.
Zhang et al. (2020) [53] Composite scaffold
4 types: unordered PLA (UP), UP/Gel (UPG), and patterned PLA/Gel (PG))
Size is between 50 nm and 100 nm BG was incorporated by coaxial electrospinning.
Bao et al. (2020) [39] 4-layer composite dressing with a micropore-array-modified Janus membrane 10 µm is the average particle size Hot pressing of a modified Janus membrane together with a bioglass layer and a superabsorbent layer.
Mao et al. (2014) [51] Vaseline-based ointment containing 45S5 BG and Yunnan Baiyao
1. Ointment I: Vaseline + 45S5
2. Ointment II: ointment I + 5% Yunnan Baiyao
3. Ointment III: ointment I + 10% Yunnan Baiyao
4. Ointment IV: ointment I + 20% Yunnan Baiyao
5. Ointment V: Vaseline + 16% Yunnan Baiyao
>53 µm Bioactive glass powder was mixed with a certain percentage of 84% melted Vaseline at 65 °C.
Lin et al. (2012) [50] 1.45S5 bioactive glass (45S5) (weight compositions: 45% SiO2, 24.5% Na2O, 24.5% CaO, and 6% P2O5)
2. 58S sol–gel bioactive glass (SGBG-58S) (weight composition: 58% SiO2, 33% CaO, and 9% P2O5)
3. Nanobioactive glass (NBG-58S) (weight composition: 58% SiO2, 33% CaO, and 9% P2O5)
>53 µm Mixed into melted Vaseline.
Tang et al. (2021) [55] 58S-BG ionic extracts.
Dilution ratios: 1/20, 1/80, 1/320
Particle size between 5 µm and 15 µm. BG extract in Dermal Cell Basal Medium.
Xie et al. (2019) [25] Vaseline-based ointment containing BG with a composition of 60% SiO2, 36%CaO, and 4% P2O5
HBG (high BG concentration)
LBG (low BG concentration)
551 ± 138 nm BG was mixed into Vaseline at different concentrations.