Table 5.
Comparison of mutation alterations between HER2-0 and HER 2-low expression tumors.
| Chrom. | Region | ALT | Type | Gene | Variant ID | Type | Function | Site | Clin Var | HER2-0 (n = 246) | HER2-Low (n = 369) |
p-Value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 | 178952085 | c.3140A>G | SNA | PIK3CA | COSM775 | missense | gain | exonic | pathogenic | 9.35% * | 17.62% * | 0.006 |
| 3 | 178916549 | AMP | CNA | PIK3CA | amplification | gain | exonic | 2.85% | 0.54% | 0.034 | ||
| 6 | 41903566 | AMP | CNA | CCND3 | amplification | gain | exonic | 2.44% | 0.27% | 0.018 | ||
| 12 | 4383096 | AMP | CNA | CCND2 | amplification | gain | exonic | 2.85% | 0.54% | 0.034 |
ALT, alteration; AMP, amplification; Chrom, chromosome; CNA, copy number alteration; SNA, single nucleotide alteration; The definition of HER2-0 and HER2-low was described in Section 4. p value was determined via Chi-Square test or Fisher’s exact test. Asterisk indicates sample frequency in percentage.