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. 2024 Jan 20;25(2):1290. doi: 10.3390/ijms25021290

Figure 4.

Figure 4

A schematic representation of HDL triggering NLRP3 activation signaling. The role of HDL in the context of myocardial infarction is illustrated along the six pivotal steps, culminating in NLRP3 activation signaling and the ultimate myocardial damage. HDL complement acronyms that could participate in the remodeling process: apolipoprotein A-I (ApoA-I); apolipoprotein A-II (ApoA-II); apolipoprotein A-V (ApoA-V); apolipoprotein C-I (ApoC-I); apolipoprotein C-III (ApoC-III); apolipoprotein C-IV (ApoC-IV); apolipoprotein D (ApoD); apolipoprotein E (ApoE); apolipoprotein F (ApoF); apolipoprotein J (ApoJ); apolipoprotein M (ApoM); apolipoprotein H (ApoH); apolipoprotein O (ApoO); apolipoprotein (ApoL-I); cholesteryl ester transfer protein (CETP); phospholipid transfer protein (PLTP); lecithin cholesterol acyltransferase (LCAT); paraoxonase-1 (PON1); paraoxonase-1 (PON3); serum amyloid A (SAA); serum amyloid A-2 (SAA2); serum amyloid A-4 (SAA4); Sphingomyelin (SM); Sphingosine 1-phosphate (S1P); microRNA (miRNas); and reactive oxygen species (ROS). ↑ means increase; ↓ means decrease.