TABLE 1.
Prechallenge immune status and ECF reactions of all animals after inoculation with sporozoite stabilate
| Vaccine | Animal | Antibody titer to p67 | Days ofa
|
Day
|
ECF reactionb | ||
|---|---|---|---|---|---|---|---|
| Pyrexia | Schizonts | Euthanized | Recovery | ||||
| SL5631 secreting p67 (i.m.) | BP78 | 1/12,800 | >10 | >11 | 18 | Severe | |
| BP79 | 1/12,800 | 8 | 9 | 22 | Moderate | ||
| BP80 | 1/25,600 | 2 | 2 | 15 | Mild | ||
| SL5631 secreting p67 (oral) | BP58 | 0 | 6 | 11 | 22 | Moderate | |
| BP59 | 0 | >10 | >12 | 18 | Severe | ||
| BP86 | 1/200 | >10 | >13 | 20 | Severe | ||
| SL5631 expressing p67 (i.m.) | BP81 | 1/1,600 | >10 | >10 | 20 | Severe | |
| BP76 | 1/1,600 | >11 | >12 | 20 | Severe | ||
| BP87 | 1/1,600 | 0 | 0 | None | |||
| None | BP77 | 0 | >11 | >11 | 18 | Severe | |
| BP90 | 0 | >9 | >12 | 18 | Severe | ||
| BP88 | 0 | >10 | >13 | 18 | Severe | ||
a
The temperature of the animals and the appearance of schizonts in the draining lymph node were evaluated daily.
b
Classification was based on clinical and parasitological examination.