Table 4.
Feline reference intervals (RIs) for serum biochemical parameters for the general feline population published in two textbooks18,19
| Analyte | Kaneko et al 18 | Outsider RI (%) | Tvedten 19 | Outsider RI (%) | Maine Coon RI |
|---|---|---|---|---|---|
| Creatinine (µmol/l) | 70.7–159 | 50 | 61.9–194.5 | 15 (0) | 35.4–150.3 |
| Urea (mmol/l) | 3.33–5.00 | 100 | 6.43–14.64 | 55 | 5.8–24.2 |
| ALT (U/l) | 6–83 | 0 | 23–109 | 30 | 8.1–72.9 |
| AST (U/l) | 26–43 | 90 | 14–41 | 20 (15) | 10.1–38.9 |
| GGT (U/l) | 1.3–5.1 | 35 | 1–3 | 45 | 0.0–8.0 |
| ALP (U/l) | 25–93 | 15 (30) | 4–81 | 15 (25) | 14.1–110 |
| Phosphorus (mmol/l) | 1.45–2.62 | 45 | 0.94–2.68 | 5 | 0.9–1.8 |
| Total protein (g/l) | 54.0–78.0 | 20 (15) | 55.0–77.0 | 20 (15) | 51.0–87.0 |
| Albumin (g/l) | 21.0–33.0 | 30 | 30.0–46.0 | 40 | 24.0–41.0 |
RIs were considered validated if ⩽10% (n = 0–2) of the Maine Coon values fell outside the published reference limits. RIs were rejected if >25% of the reference values (n ⩾5) fell outside the reference limits. If >10% but <25% of the reference values (n = 3–4) fell outside the reference limits, a new set of 20 animals was randomly selected and their reference values compared with the RIs. In the new set-up, if ⩽10% of the samples fell outside the RIs, then the laboratory RI was considered validated; otherwise, it was rejected. When the published RI was rejected, a new RI, reported in bold, was established following the Clinical and Laboratory Standards Institute and American Society of Veterinary Clinical Pathology guidelines15,16
ALT = alanine aminotransferase; AST = aspartate aminotransferase; GGT = γ-glutamyl transpeptidase; ALP = alkaline phosphatase