Table 2.
Side Effects |
Bacterial | Mycobacterial | |||
---|---|---|---|---|---|
Clinical measures | Staphylococcus aureus/Streptococcus pyogenes/Clostridium difficile/Pseudomonas aeruginosa [3,55] | Mycobacterium tuberculosis/Mycobacterium bovis [3,7,17,58,59] | Mycobacterium chelonae/Mycobacterium abscessus/Mycobacterium fortuitum [6,15,16] | Mycobacterium mageritense [3,60,61] | Mycobacterium leprae [1,3,62] |
Standard bacterial infection management | Multidrug therapy administered in two phases [63]: Isoniazid Rifampicin Pyrazinamide Ethambutol or Streptomycin |
Macrolide antibiotics [64] (Clarithromycin) 4 months in mild cases 6–12 months in severe cases |
Antibiotic therapy [64]: Amikacin Imipenem Cefoxitin Fluroquinolones Sulfonamides |
Paucibacillary disease [65]: Dapsone + Rifampicin + Clofazimine for 6 months |
|
Multibacillary disease [65]: Dapsone + Rifampicin + Clofazimine for 12 months | |||||
Rifampicin resistance [65]: 24 months treatment broken down as 6 months of Clofazimine + Ofloxacin and Minocycline followed by 18 months of Clofazimine + Ofloxacin or Minocycline | |||||
Dapsone resistance [65]: Clofazimine + Rifampicin for 6 months |