Table 3.
Ronidazole pharmacokinetic values in 10 cats (five infected by Tritrichomonas foetus and five uninfected) after a single dose of guar gum ronidazole capsules
| Parameters | Units | Cats not infected by T foetus |
Cats infected by T foetus |
P value | ||||
|---|---|---|---|---|---|---|---|---|
| Geometric mean | Range of each parameter | SD | Geometric mean | Range of each parameter | SD | |||
| AUC | μg/h/ml | 467.3 | 415.4–528.3 | 47.0 | 481.0 | 357.0–900.4 | 230.3 | 0.687 |
| Cmax | μg/ml | 21.6 | 18.5–28.5 | 4.0 | 17.1 | 10.7–32.8 | 9.2 | 0.499 |
| MRT | h | 21.3 | 16.4–23.2 | 2.9 | 30.8 | 15.6–47.2 | 13.1 | 0.125 |
| Tmax | h | 9.0 | 6.0–12.0 | 2.3 | 9.4 | 6.0–16.0 | 4.0 | 0.708 |
AUC = area under the curve from time zero to infinity; Cmax = maximum plasma concentration; MRT = mean residence time; Tmax = time to maximum plasma concentration