Figure 4.

The LPL model was built on the assumption that the cell’s repair rate of DNA strand breaks is fixed and that the dose rate can be variable [40]. η represents the implicit dose rate and ε is the repair rate. Dose to the viable cells could produce potentially lethal (PL) lesions which could be repaired, but if misrepaired, or if the repair is not fast enough to combat the rate of lesion production, then the PL lesions can become lethal lesions and result in clonogenic cell death. If the repair rate is greater than the dose rate, and if any misrepairs do not impede the cell’s ability to proliferate, then the PL lesions are resolved, and the cell returns to its viable state [12]. Figure adapted from Joiner et al. [12].