Table 1.
Hormonal particularities of FFA female patients.
| First Author, Year | Type of Study | Studied Population | Sex Hormone Statuses |
|---|---|---|---|
| Kanti 2019 [36] |
Observational, cross-sectional study | N = 490 FFA patients N1 = 467 (95%) female FFA patients N2 = 23 (5%) male patients with FFA |
N1 = 33 (88%) Testosterone (T)values within normal range N2 = 28 (96%) DHEAS values normal in tested women N3 = 26 (92%) SHBG values normal in tested women N4 = 0 abnormal PRL values N5 = 0 abnormal free androgen index |
| Nasiri 2020 [46] |
Case-control study | N1= 30 women with FFA N2 = 34 healthy age and menopausal status matched controls |
N1 = 12.93 PRL (ng/mL) median in FFA patients N2 = 11.69 PRL (ng/mL) median in controls p = 0.882 N3 = 10.24 Luteinizing hormone (LH) (mIU/mL) median in FFA patients N4 = 11.69 LH (mIU/mL) median in controls p = 0.619 N5 = 24.21 FSH (mIU/mL) median in FFA patients N6 = 27.72 FSH (mIU/mL) median in controls p = 0.288 N7 = 0.12 17-Hydroxyprogesterone (17-OH-prog) (ng/mL) median in FFA patients N8 = 0.36 17-OH-prog (ng/mL) median in controls p = 0.275 N9 = 0.97 Free T (pg/mL) median in FFA patients N10 = 1.4 Free T (pg/mL) median in controls p = 0.135 N11 = 79.26 DHEA-S (µg/dL) median in FFA patients N12 = 152.34 DHEA-S (µg/dL) median in controls p = 0.038 N13 = 1.41 Androstenedione (A4) (ng/mL) median in FFA patients N14 = 2.31 A4(ng/mL) median in controls p = 0.012 |
| Sasannia 2020 [33] |
Case-control retrospective study | N1 = 20 women with FFA (mean age of 46.9 years) N2 = 20 healthy controls (mean age of 47.20 years) |
N1 = 6.40 Mean LH (IU/L) in FFA cases N2 = 9.72 Mean LH (IU/L) in controls p = 0.52 N3 = 9.00 Mean FSH (IU/L) in FFA cases N4 = 15.11 Mean FSH (IU/L) in controls p = 0.03 N5 = 19.88 Mean PRL (ng/mL) in FFA cases N6 = 20.63 Mean PRL (ng/mL) in controls p = 0.44 N7 = 0.42 Mean Total T (ng/mL) in FFA cases N8 = 0.40 Mean Total T (ng/mL) in controls p = 0.58 N9 = 1.28 Mean Free T (pg/mL) in FFA cases N10 = 1.57 Mean Free T (pg/mL) in controls p = 0.48 N11 = 123.87 Mean DHEAS (µg/dL) in FFA cases N12 = 172.75 Mean DHEAS (µg/dL) in controls p = 0.2 N13 = 38.09 Mean LH (IU/L) in Postmenopausal at onset FFA cases N14 = 19.70 Mean LH (IU/L) in Cyclic at onset FFA cases N15 = 55.27 Mean FSH (IU/L) in Postmenopausal at onset FFA cases N16 = 36.72 Mean FSH (IU/L) in Cyclic at onset FFA cases N17 = 11.68 Mean PRL (ng/mL) in Postmenopausal at onset FFA cases N18 = 6.40 Mean PRL (ng/mL) in Cyclic at onset FFA cases N19 = 0.35 Mean Total T (ng/mL) in Postmenopausal at onset FFA cases N20 = 0.31 Mean Total T (ng/mL) in Cyclic at onset FFA cases N21 = 0.84 Mean Free T (pg/mL) in Postmenopausal at onset FFA cases N22 = 0.72 Mean Free T (pg/mL) in Cyclic at onset FFA cases N23 = 52.66 Mean DHEAS (µg/dL) in Postmenopausal at onset FFA cases N24 = 71.00 Mean DHEAS (µg/dL) in Cyclic at onset FFA cases |
| Bernárdez 2017 [32] |
Retrospective study | N = 43 premenopausal women with FFA N1 = 42.5 years, median age |
N1 = 91% FSH within normal range N2 = 87% LH within normal range N3 = 82% Estradiol within normal range N4 = 97% A4 within normal range N5 = 90% 17-OH-P within normal range N6 = 90% PRL within normal range N7 = 100% DHEA-s within normal range N8 = 92% T within normal range N9 = 39 (91%) had hormone profiles expected of fertile women N10 = 4 (9%) had alterations suggestive of perimenopause |
| Ranasinghe 2017 [38] |
Retrospective study | N = 53 women with FFA | N1 = 9 (17.0%) androgen excess/PCOS N2 = 17 (32.1%) low androgens N3 = 9 (17.0%) low/high androgens N4 = 2 (3.8%) hirsute/low androgens N5 = 9 (17.0%) ovarian cyst only N6 = 2 (3.8%) Ovarian cyst/low T |