Table 2.
Fertile status in women with FFA.
| First Author, Year | Type of Study | Studied Population | Fertile Statuses |
|---|---|---|---|
| Banka 2014 [49] |
Retrospective study | N = 62 patients with FFA N1 = 61 females |
Menopausal N = 49 (80%) Premenopausal N = 12 (20%) |
| Grassi 2021 [48] |
Retrospective study | N = 119 patients with FFA N1 = 8 men N2 = 111 female |
N1 = 101, (91.0%) Menopausal at onset of FFA N2 = 10 (9.0%) Premenopausal at onset of FFA N3 = 50.9 years mean age at menopause onset |
| Buendía-Castaño 2018 [54] |
Case-control study | N1 = 104 female FFA patients N2 = 208 age-matched controls |
N1 = 47.7 age of menopause for FFA patients N2 = 49.7 years, age of menopause for controls p = 0.01 N3 = 34.8 years of fertile life for FFA patients N4 = 36.5 years of fertile life for the control group p = 0.004 N5 = 94 (91.3%) postmenopausal FFA patients N6 = 189 (90.9%) postmenopausal controls |
| Panchaprateep 2020 [57] |
Retro-prospective cohort study | N = 58 patients with FFA | N1 = 53 (91.4%) Menopause status at present N2 = 16 (27.6%) Onset at pre-menopause N3 = 48 (46–51) Mean age of menopause N4= 20 (37.7%) Surgical menopause |
| Imhof 2018 [50] |
Retrospective study | N = 148 female FFA patients | N1 = 57,4 mean age at onset of symptoms N2 = 129 (87.2%) postmenopausal at presentation N3 = 14 (9.4%) premenopausal at presentation N4 = 5 (3.4%) menopause status undisclosed. N5 = 48.9 years mean age of menopause |
| Tan 2009 [58] |
Retrospective study | N1 = 18 patients with FFA | N1 = 15 (83%) menopausal N2 = 3 (17%) premenopausal N3 = 55.5 mean age of onset (range 34–71) |
| Müller Ramos 2021 [51] |
Case-control study | N1 = 451 FFA patients N2 = 451 sex-matched controls N3 = 434 (96%) females N4 = 17 (4%) males |
N1 = 272 (60%) menopausal FFA patients N2 = 200 (44%) menopausal controls N3 = 47 years mean age of disease onset near menopause |
| Vañó-Galván 2013 [55] |
Retrospective study | N = 355 patients with FFA N1= 343 women with FFA N2= 12 men with FFA N3 = 61 years mean age (range 23–86) |
N1 = 294 menopausal women N2 = 49 premenopausal women N3 = 49 years (range 23–60) mean age of menopause N4 = 49 (14%) females with early menopause (<45 years) N4.1 = 31(9%) surgical menopause N5 = 56 years (range 21–81) mean age of onset of FFA |
| Starace 2019 [52] |
Case-control study | N = 65 females with FFA N2 = 62.5 years (range 42–87) mean age |
N1 = 57 (87.75%) menopausal N2 = 8 (12.25) premenopausal N3 = 51.5 years (43–61 years) mean age at menopause onset N4 = 6 (10.5%) had developed premature menopause (≤45 years) N4.1 = 3 (4.6%) had hysterectomy N5 = 9 (13.8%) reported prolonged of irregular menses N6 = 10.3 years average time between the onset of menopause and the development of FFA |
| Conde Fernandes 2011 [53] |
Retrospective study | N = 11 women with FFA N1 = 64.9 years mean age |
N1 = 10 (90.9%) postmenopausal women N2 = 1 (0.1%) premenopausal woman |
| Mervis 2019 [59] |
Retrospective study | N = 91 patients with FFA N1 = 87 women N2 = 4 men N3 = 59.6 years mean age |
N1 = 30 (34%) premenopausal at first visit |
| Dlova 2013 [60] |
Retrospective study | N= 20 patients with FFA N1 = 19(95%) female N2 = 1 (5%) male N3 = 42 yrs mean age of onset |
N1 = 14 (73%) premenopausal N2 = 4 (27%) menopausal |
| Tosti 2005 [61] |
Retrospective study | N = 14 women with FFA N1 = 62 years mean age (range 54 and 78 years) |
N1 = 14 (100%) menopausal N2 = 5.5 yeas mean time (range 2–12 years) from menopause to disease onset |
| Kanti 2019 [36] |
Observational, cross-sectional study | N = 490 FFA patients N1 = 467 (95%) female FFA patients N2 = 23 (5%) male patients with FFA N3 = 60 years mean age of onset (IQR 53–68 years) |
N1 = 84% women were postmenopausal |
| Moreno-Arrones 2019 [14] |
Case-Control study | N1 = 578 women N2 = 289 women with FFA N3 = 289 female controls N4 = 77 men N5 = 19 men with FFA N6 = 58 male controls |
N1 = 34.2 (17–48) number of reproductive years-controls N2 = 34.5 (15–52) number of reproductive years-FFA p = 0.59 N3 = 219 (75.8%) controls who had pregnancies N4= 241 (83.4%) cases who had pregnancies p = 0.03 |
| Nasiri 2020 [46] |
Case-control study | N1= 30 women with FFA N2 = 34 healthy age and menopausal status matched controls N3 = 51.07 ± 9.22 years–mean age of FFA patients N4 = 51.15 ± 8.16 years–mean age of controls |
N1 = 15 (50.0%) patients with FFA were postmenopausal N2 = 15 (50.0%) patients with FFA were premenopausal N3 = 19(55.9%) controls were postmenopausal N4 = 15(44.1%) controls were premenopausal |
| MacDonald 2012 [28] |
Retrospective study | N = 60 women with FFA | N1 = 3 (5%) premenopausal N2 = 55 (95%) menopausal |
| Suchonwanit 2020 [62] |
Retrospective study | N = 56 patients with FFA N1 = 54 (96.4%) women with FFA N2 = 2(3.6%) men with FFA N3 = 51 years–average age of disease onset (range, 39–80 years) |
N1 = 48 (88.9%) postmenopausal women N2 = 8 (11.1%) premenopausal women |
| Heppt 2018 [47] |
Retrospective study | N = 72 FFA patients N1 = 70 (97.2%) women N2 = 2 (2.8%) men |
N1 = 57 (81.4%) Postmenopausal N2 = 6 (8.6%) Premenopausal N3 = 7 (10.0%) Unknown menopausal status |
| Sasannia 2020 [33] |
Case-control retrospective study |
N1 = 20 women with FFA (mean age of 46.9 years) N2 = 20 healthy controls (mean age of 47.20 years) |
N1 = 8 participants were postmenopausal in each group N2 = 12 participants were cyclic in each group N3 = 6 presented the disease after the onset of menopause |
| Bernárdez 2017 [32] |
Retrospective study | N = 43 premenopausal women with FFA N1 = 42.5 years, median age |
N = 43 (100%) premenopausal |
| Meinhard 2014 [56] |
Retrospective study | N1 = 31 women with FFA N2 = 1 man with FFA |
N = 95.5% postmenopausal |