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. 2024 Jan 12;22(1):44. doi: 10.3390/md22010044

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of CP on body weight and histopathological changes in DNCB-induced AD mouse model. (A) Changes in body weight of DNCB-induced AD mice during the experiment. (B) Clinical severity of inflammatory skin lesions. Photographs were taken on day 28. (C,E,F) The thicknesses of the epidermis and dermis were examined by Masson’s trichrome staining of the skin sections. (D) The infiltration of mast cells in the dermis was examined by toluidine blue staining of the skin section. (G) The mast cells were counted in 3 fields. All results are shown as the mean ± SD (n = 5 per group). ## p < 0.01 compared to the control group. * p < 0.05 and ** p < 0.01, compared to the DNCB group. Normal, untreated group; DNCB, DNCB-sensitized group; CP, 1 mg CP-treated group; Terfenadine, 0.1 mg Terfenadine-treated group; E, epidermal thickness; D, dermal thickness.

Effect of CP on body weight and histopathological changes in DNCB-induced AD mouse model. (A) Changes in body weight of DNCB-induced AD mice during the experiment. (B) Clinical severity of inflammatory skin lesions. Photographs were taken on day 28. (C,E,F) The thicknesses of the epidermis and dermis were examined by Masson’s trichrome staining of the skin sections. (D) The infiltration of mast cells in the dermis was examined by toluidine blue staining of the skin section. (G) The mast cells were counted in 3 fields. All results are shown as the mean ± SD (n = 5 per group). ## p < 0.01 compared to the control group. * p < 0.05 and ** p < 0.01, compared to the DNCB group. Normal, untreated group; DNCB, DNCB-sensitized group; CP, 1 mg CP-treated group; Terfenadine, 0.1 mg Terfenadine-treated group; E, epidermal thickness; D, dermal thickness.