Table 1.
Patients’ characteristics.
| Overall (n = 157, 100%) |
FI (n = 13, 8%) |
Fungal Colonization (n = 36, 23%) |
Others (n = 108, 69%) |
p-Value | Multivariable Analysis OR [95% CI], p-Value |
|
|---|---|---|---|---|---|---|
| Baseline characteristics | ||||||
| Age, years, median (IQR) | 54 (41–60) | 50 (35.5–57.5) | 48 (36.75–60.25) | 55 (46–61) | 0.19 | - |
| Sex, male, n (%) | 102 (65) | 8 (61) | 24 (67) | 70 (65) | 0.94 | - |
| BMI, kg/m2, median (IQR) | 24 (20–26) | 25 (24–25) | 22 (18–28) | 23 (18–27) | 0.61 | - |
| Patients on Corticosteroids, n (%) | 84 (54) | 5 (38) | 21 (58) | 58 (54) | 0.48 | - |
| Patients on O2 therapy, n (%) | 141 (90) | 11 (85) | 33 (92) | 97 (90) | 0.77 | - |
| Diabetes, n (%) | 28 (19) | 1 (7) | 5 (14) | 22 (20) | 0.41 | - |
| Oto score, median (IQR) | 5 (2–44) | 4 (1–6) | 5 (2–24) | 5 (2–50) | 0.35 | - |
| LAS score, median (IQR) | 34 (32–38) | 38 (38–38) | 34 (31–34) | 33 (26–36) | 0.20 | - |
| Time from admission, days, n (%) | 147 (94) | 11 (85) | 34 (94) | 102 (94) | 0.38 | - |
| Underlying disease | ||||||
| Septal a, n (%) | 31 (19) | 3 (23) | 12 (33) | 16 (15) | 0.05 | - |
| Interstitial b, n (%) | 61 (39) | 4 (31) | 11 (31) | 46 (43) | 0.36 | - |
| Obstructive c, n (%) | 23 (15) | 0 (0) | 6 (17) | 17 (16) | 0.29 | - |
| Others d, n (%) | 42 (27) | 6 (46) | 7 (19) | 29 (27) | 0.18 | - |
| Previous colonization | ||||||
| Recipient-related bacteria, n (%) | 41 (26) | 4 (31) | 11 (31) | 26 (24) | 0.045 | 2.23 [0.03–7], p = 0.78 |
| Recipient-related fungi, n (%) | 7 (5) | 2 (15) | 2 (6) | 3 (3) | 0.19 | - |
| Recipient-related virus, n (%) | 35 (22) | 4 (31) | 12 (33) | 19 (18) | 0.003 | 2.48 [1.05–4.61], p = 0.52 |
| Donor-related bacteria, n (%) | 77 (49) | 6 (46) | 17 (47) | 54 (50) | 0.83 | - |
| Donor-related fungi, n (%) | 20 (13) | 1 (8) | 7 (19) | 12 (11) | 0.22 | - |
Data are expressed as number and (percentage) or median and [interquartile range or IQR]. a Septic: cystic fibrosis, bronchiectasis; b Interstitial: idiopathic pulmonary fibrosis, allergic extrinsic alveolitis, non-specific interstitial pneumonia, fibrosing emphysema, lymphocytic interstitial pneumonia, respiratory bronchiolitis interstitial lung; c Obstructive: chronic obstructive pulmonary disease; d Others: idiopathic pulmonary hypertension, veno-occlusive disease, connective tissue disease, α1-anti-trypsin deficiency, lymphangioleiomyomatosis, histiocytosis, sarcoidosis, graft versus host disease. Abbreviations: FI Fungal Infection, BMI, body mass index; n, number; O2, oxygen; LAS, lung allocation score; OR, odds ratio; CI, confidential interval; IQR, interquartile range.