Figure 3. I0 and acute influenza infection immune landscape.
(A) Examples of I0 determinant profiles for two infants (purple dots), two adults (blue/green dots), and two elderly subjects, highlighting the vast variation of factors that lead to different positions within the immune landscape. (B) Immune landscape during baseline and acute immune states. (C) Example trajectories (from panel B) of ‘Adult’ and ‘Extremes of Age’ subjects with varying degrees of influenza disease severity. Arrows correspond to major contributing factors driving a subject’s location within the landscape, and the length of the arrow is associated with the magnitude of the effect of that factor.