Figure 6. I0 and SARS-CoV-2 infection immune landscape.
Provisional model of the immunological landscape related to coronavirus disease (COVID). Although more studies are needed to refine specific immune profiles, what we know of the immune response to and presentation of SARS-CoV-2 infection suggests it has a distinct landscape compared to influenza. Mathew, et al. identified three cellular-based immunophenotypes associated with COVID outcome (Mathew et al., 2020). However, it’s unclear how these profiles relate to other immunological signatures of COVID disease presentation. Studies have reported mixed associations between cytokine storm and illness outcome, thus this cluster profile spans the threshold for severe disease (Leisman et al., 2020). Lastly, the acute landscape component includes the post-infectious period in order to incorporate complications such as multisystem inflammatory syndrome in children (MIS-C).