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. 2023 Jun 28;4(2):104–114. doi: 10.12336/biomatertransl.2023.02.005

Figure 4. Morphological assessment of the perforated micromachined fibre mesh. (A, B) First cytotoxicity test of the 500 μm micromachined PLGA mesh. (A) Light Microscopy image of the micromachined array showing good circularity. (B) Live/dead image showing excellent cell viability and the holes clearly defined. (C–F) Light microscopy images of the 200 (C), 300 (D), 400 (E), and 500 (F) μm hole arrays, which show good circularity and even distribution. (G–J) Epifluorescent microscope images of live ADSCs on the micromachined fibre mesh with 200 (G), 300 (H), 400 (I), and 500 (J) μm hole arrays, with excellent cell viability seen across all samples, and ‘bridging’ of cells across. (K–M) Light microscope images of three selected micromachined electrospun PCL fibre mesh samples, all micromachined with the same setting but with minor variances as a result of the non-uniform thickness of the PCL nanofibre mesh. Scale bars: 500 μm. PCL: polycaprolactone; PLGA: polylactic-co-glycolic acid.

Figure 4.