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Schematic representation of this study. APC mutations disrupt the β-catenin destruction complex condensates organized by phase separation in CRC cells. And truncated APC did not affect the formation of condensates, but GSK 3β and CK1α were unsuccessfully recruited and resulting in accumulation in the cytoplasm of CRCs. Furthermore, Axin participated in the β-catenin nuclear translocation and recruitment into the transcription condensation, driving the progression of CRC
