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. 2024 Jan 26;7:131. doi: 10.1038/s42003-024-05826-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The UMAP plot shows epithelial cell sub cluster by color. b Dot plot shows gene module contribution of epithelial cell sub cluster. c The expression heatmap of top10 marker genes for epithelial cell sub cluster. d Heatmaps shows large-scale CNVs for individual epithelial cells. e The violin plot shows the cell entropy value of epithelial cells in each stage (Total 23,564 single cell). *P < 0.05; **P < 0.01; ***P < 0.001, ****P < 0.0001. f The violin plot shows the CNV score of epithelial cells in each stage (Total 2,488 single cells). g The heatmap shows the tumor cell function gene sets score of each stage. h The bar chart shows the GO enrichment term of up regulated genes in stage IC2.