Table 1.
Candidate windows and genes under positive selection signatures in Nigerian indigenous chickens in relation to heat stress adaptation based on Hp analysis.
| Sweep regions | Candidate genes and functions |
|---|---|
| Chr 2: 131020000–131040000 |
Contains multiple lncRNAs with possible cis-regulatory function on the nearby gene (HSF1) HSF1 (Heat Shock Factor 1): 26 kb upstream, encodes a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements18,19 |
| Chr 5: 41000000–41020000 | TSHR: Role in thermogenesis20,21 |
| Chr 14: 16010000–16030000 | LIPE: Hormone-sensitive lipase activity22,23 |
| Chr 22: 40000–60000 | SFTPB: Pulmonary surfactant protein; role in respiratory gaseous exchange24,25 |
| Chr 30: 10000–30000 |
SLC44A2: Choline transport (important for the nervous system); involved in positive regulation of I-kappaB kinase17,22,26 Nearby gene: ILF3 (16 kb downstream) has a role in chronic stress adaptation27 |
| Chr 30: 200000–220000 |
LOC107050992: iron-sulpher binding and electron transfer activity17,22 |
| Chr 32: 0–20000 | LOC112530475 and LOC101748756: both RYR1 like genes; RYR1 is involved in calcium channel activity and calmodulin-binding17,22 |
| Chr 32: 590000–610000 |
LOC112530469 and LOC101749846: Both are cytochrome P450 like genes; oxidoreductase activity and heme-binding17,22 STRN4: Calmodulin binding and calcium channel activities22 |