. 2024 Jan 26;14:2209. doi: 10.1038/s41598-024-52569-4

Table 3.

Protein coding genes overlapping with putative selection signatures in populations from hot-humid conditions.

Sweep regions	Relevant biological functions for the candidate genes
Chr5: 29080000–29100000	ARG2: mitochondrial type of arginase that leads to an increase in oxygen-free radical formation and endothelial dysfunction⁴⁴, arginine metabolism is also a critical regulator of innate and adaptive immune responses⁴⁵
Chr7: 11480000–11500000	VTI1B: concerned with increased secretion of cytokines associated with cellular senescence¹⁶ STRADB: among its related pathways are MTOR signalling and AMP-activated protein kinase signalling²² TRAK2: Predicted to be involved in several processes, e.g., mitochondrion distribution; organelle transport along the microtubule and protein targeting²²

Sweep regions

Relevant biological functions for the candidate genes

Chr5: 29080000–29100000

ARG2: mitochondrial type of arginase that leads to an increase in oxygen-free radical formation and endothelial dysfunction⁴⁴, arginine metabolism is also a critical regulator of innate and adaptive immune responses⁴⁵

Chr7: 11480000–11500000

VTI1B: concerned with increased secretion of cytokines associated with cellular senescence¹⁶

STRADB: among its related pathways are MTOR signalling and AMP-activated protein kinase signalling²²

TRAK2: Predicted to be involved in several processes, e.g., mitochondrion distribution; organelle transport along the microtubule and protein targeting²²