Table 3.

Test Performance: Diagnostic Accuracy Parameters of Molecular Diagnostics and [¹⁸F]FDG-PET/CT in Nononcocytic Nodules (n = 86)

A priori ROM 26%	MD		[18F]FDG-PET/CT		p
	Histopathology
Test result	Malignant or borderline	Benign	Malignant or borderline	Benign
Positive	17	15	20	30
Negative	5	49	2	34
MD on cytology (n = 86), assuming nodules under active surveillance are benign, % [CI]
Sensitivity	77 [55–92]		91 [71–99]		0.22
Specificity	77 [64–86]		53 [40–66]		0.01
PPV	53 [35–71]		40 [26–55]
NPV	91 [80–97]		94 [81–99]
BCR	63 [52–73]		42 [31–53]

Separate diagnostic accuracy parameters of MD and [¹⁸F]FDG-PET/CT for AUS and FN nodules are given in Supplementary Table S3.

AUS, atypia of undetermined significance.