Table 1. Baseline characteristics of patients with or without HOPR.
| Variables | HOPR | Non-HOPR | P-value | |||
| N | [n (%)] or (mean±SD) | N | [n (%)] or (mean±SD) | |||
|
Abbreviations: HOPR, high on-treatment platelet reactivity; BMI, body mass index; PCI, percutaneous coronary intervention; RBC, red blood cell; WBC, white blood cell; ALT, alanine transaminase; LDH, lactate dehydrogenase; γ-GGT, gamma-glutamyl transpeptidase; TBIL, total bilirubin; DBIL, direct bilirubin; IBIL, indirect bilirubin; BUN, blood urea nitrogen; FBG, fasting blood glucose; HbA1c, hemoglobin A1c; TC, total cholesterol; TG, total triglyceride; LDL, low density lipoprotein; HDL, high density lipoprotein; Lp(a), lipoprotein (a); CK-MB, creatine kinase-MB; PCT, procalcitonin; CRP, C-reactive protein; PT, prothrombin time; APTT, activated partial thromboplastin time; INR, international normalized ratio; PLADP, platelet aggregation induced by adenosine diphosphate; PLAA, platelet aggregation induced by arachidonic acid; PPIs, proton pump inhibitors; CCBs, calcium channel blockers; SA, stable angina; UA, unstable angina; NSTEMI, non-ST-elevation myocardial infarction; STEMI, ST-elevation myocardial infarction; SD, standard deviation. | ||||||
| Female | 389 | 117 (30.1) | 1260 | 294 (23.3) | 0.007 | |
| Age (years) | 389 | 64.4±10.3 | 1260 | 63.6±10.5 | 0.201 | |
| BMI (kg/m2) | 373 | 25.0±3.0 | 1182 | 24.6±3.1 | 0.023 | |
| Smoking | 387 | 160 (41.3) | 1251 | 600 (48.0) | 0.023 | |
| Drinking | 386 | 80 (20.7) | 1248 | 314 (25.2) | 0.075 | |
| Hypertension | 388 | 260 (67.0) | 1258 | 831 (66.1) | 0.728 | |
| Diabetes mellitus | 387 | 100 (25.8) | 1253 | 331 (26.4) | 0.822 | |
| Hyperlipidemia | 330 | 33 (10.0) | 852 | 81 (9.5) | 0.797 | |
| PCI history | 385 | 25 (6.5) | 1249 | 127 (10.2) | 0.030 | |
| RBC (1012/L) | 384 | 4.4±0.5 | 1237 | 4.5±0.6 | 0.010 | |
| Hemoglobin (g/L) | 384 | 134.1±15.3 | 1238 | 135.8±17.7 | 0.100 | |
| WBC (109/L) | 384 | 7.4±3.0 | 1238 | 6.9±2.4 | 0.004 | |
| Neutrophil ratio (%) | 384 | 64.0±11.8 | 1236 | 63.4±10.1 | 0.398 | |
| Platelet (109/L) | 384 | 189.2±56.4 | 1238 | 195.2±63.4 | 0.094 | |
| ALT (U/L) | 380 | 37.5±34.8 | 1242 | 36.3±50.3 | 0.660 | |
| LDH (U/L) | 374 | 310.0±338.9 | 1216 | 265.1±255.9 | 0.018 | |
| γ-GGT (U/L) | 344 | 44.2±65.0 | 1192 | 47.2±93.4 | 0.585 | |
| TBIL (µmol/L) | 346 | 13.3±6.1 | 1200 | 13.6±24.9 | 0.849 | |
| DBIL (µmol/L) | 345 | 4.2±2.1 | 1194 | 6.5±62.7 | 0.504 | |
| IBIL (µmol/L) | 345 | 9.1±4.4 | 1189 | 8.6±4.5 | 0.087 | |
| BUN (mmol/L) | 380 | 6.0±3.7 | 1238 | 8.0±41.1 | 0.347 | |
| Creatinine (µmol/L) | 380 | 77.9±22.0 | 1240 | 80.7±40.8 | 0.209 | |
| Uric acid (µmol/L) | 374 | 332.1±99.0 | 1221 | 346.1±93.8 | 0.013 | |
| FBG (mmol/L) | 370 | 6.3±2.2 | 1194 | 6.0±2.0 | 0.027 | |
| HbA1c (%) | 135 | 6.8±1.7 | 411 | 6.8±1.5 | 0.567 | |
| TC (mmol/l) | 373 | 4.3±1.2 | 1221 | 4.3±2.1 | 0.911 | |
| TG (mmol/L) | 374 | 1.6±0.9 | 1222 | 1.9±5.9 | 0.325 | |
| LDL-C (mmol/L) | 374 | 2.6±0.9 | 1220 | 3.4±12.1 | 0.231 | |
| HDL-C (mmol/L) | 374 | 1.1±0.3 | 1220 | 1.3±5.5 | 0.569 | |
| Lp(a) (mg/L) | 367 | 280.4±249.7 | 1210 | 282.7±267.2 | 0.883 | |
| CK-MB (ng/mL) | 312 | 39.1±79.1 | 968 | 36.4±138.7 | 0.750 | |
| PCT (ng/mL) | 135 | 0.4±1.3 | 370 | 1.0±2.8 | < 0.001 | |
| CRP (mg/L) | 82 | 8.8±19.9 | 241 | 7.3±18.9 | 0.551 | |
| PT (s) | 332 | 11.9±1.2 | 1163 | 11.9±1.4 | 0.578 | |
| APTT (s) | 329 | 48.2±394.5 | 1160 | 26.7±9.9 | 0.323 | |
| INR | 332 | 1.4±3.1 | 1160 | 1.1±1.7 | 0.129 | |
| PLADP (%) | 389 | 50.4±7.7 | 1260 | 24.5±9.4 | < 0.001 | |
| PLAA (%) | 389 | 5.2±9.8 | 1260 | 4.0±4.6 | 0.017 | |
| PPIs | 389 | 72 (18.5) | 1260 | 233 (18.5) | 0.994 | |
| Statins | 389 | 367 (94.3) | 1260 | 1128 (89.5) | 0.004 | |
| CCBs | 389 | 136 (35.0) | 1260 | 413 (32.8) | 0.424 | |
| Diagnoses | 377 | 1234 | 0.033 | |||
| SA | 69 | 69 (18.3) | 305 | 305 (24.7) | ||
| UA | 187 | 187 (49.6) | 605 | 605 (49.0) | ||
| NSTEMI | 34 | 34 (9.0) | 88 | 88 (7.2) | ||
| STEMI | 87 | 87 (23.1) | 236 | 236 (19.1) | ||