Table 1.

Performance of the Fully Automated AI Model for Detecting nGA in the Combined Validation Test Sets

Training and Tuning Specificity∗	All Visits		At First Development†
	Sensitivity	Specificity	Sensitivity	Specificity
0.99	0.76 (0.67–0.84)	0.98 (0.96–0.99)	0.53 (0.40–0.65)	0.98 (0.96–0.99)
0.98	0.86 (0.77–0.93)	0.97 (0.95–0.99)	0.75 (0.62–0.87)	0.97 (0.95–0.99)
0.95	0.91 (0.83–0.98)	0.94 (0.91–0.97)	0.87 (0.77–0.97)	0.94 (0.91–0.97)

All values are presented as the estimate (95% confidence interval). AI = artificial intelligence; nGA = nascent geographic atrophy.

^∗Based on threshold determined from the training and tuning sets.

^†Including all OCT volume scans up until the visit of nGA development, or until the final visit if nGA did not develop in an eye.