Table 1.
Formulation composition of the various SARS-CoV-2 sub-unit vaccines containing RBD and TLR ligands.
| Formulation Composition | Concentration of the Adsorbant (µg/mL) | Concentration of the Adsorbate (µg/mL) | ||||||
|---|---|---|---|---|---|---|---|---|
| AH | AP | RBD | INI-4001 | INI-2002 | ||||
| 2% Glycerin | TRIS Buffer | 2% Glycerin | TRIS Buffer | 2% Glycerin | TRIS Buffer | |||
| RBD | 0 | 0 | 20 | 20 | 0 | 0 | 0 | 0 |
| 2% glycerin | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| INI-4001 only | 0 | 0 | 0 | 0 | 200.00 | 200.00 | 0 | 0 |
| INI-2002 only | 0 | 0 | 0 | 0 | 0 | 0 | 20.00 | 20.00 |
| INI-4001 + INI-2002 | 0 | 0 | 0 | 0 | 200.00 | 200.00 | 20.00 | 20.00 |
| Alhydrogel | 480 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| RBD + Alhydrogel (1:2) | 40 | 0 | 20 | 20 | 0.00 | 0.00 | 0 | 0 |
| RBD + Alhydrogel (1:24) | 480 | 0 | 20 | 20 | 0.00 | 0.00 | 0 | 0 |
| INI-4001 + Alhydrogel | 400 | 0 | 0 | 0 | 200.00 | 200.00 | 0 | 0 |
| INI-2002 + Alhydrogel | 40 | 0 | 0 | 0 | 0.00 | 0.00 | 20.00 | 20.00 |
| INI-2002 + Alhydrogel (10 times) | 40 | 0 | 0 | 0 | 0.00 | 0.00 | 200.00 | 200.00 |
| INI-4001 + INI-2002 + Alhydrogel | 440 | 0 | 0 | 0 | 200.00 | 200.00 | 20.00 | 20.00 |
| INI-4001 + INI-2002 + Alhydrogel (10:10) | 440 | 0 | 0 | 0 | 200.00 | 200.00 | 200.00 | 200.00 |
| RBD + INI-4001 + Alhydrogel | 440 | 0 | 20 | 20 | 200.00 | 200.00 | 0 | 0 |
| RBD + INI-2002 + Alhydrogel | 80 | 0 | 20 | 20 | 0.00 | 0.00 | 20.00 | 20.00 |
| INI-2002 (10X) + Alhydrogel | 80 | 0 | 20 | 20 | 0.00 | 0.00 | 200 | 200 |
| RBD + INI-4001 + INI-2002 + Alhydrogel | 480 | 0 | 20 | 20 | 200.00 | 200.00 | 20.00 | 20.00 |
| RBD + INI-4001 + INI-2002 (10X) + Alhydrogel | 480 | 0 | 20 | 20 | 200.00 | 200.00 | 200.00 | 200.00 |
| Adju-Phos | 0 | 40 | 0 | 0 | 0 | 0 | 0 | 0 |
| RBD + Adju-Phos | 0 | 40 | 20 | 20 | 0.00 | 0.00 | 0 | 0 |
| INI-4001 + Adju-Phos | 0 | 400 | 0 | 0 | 200.00 | 0.00 | 0 | 0 |
| INI-2002 + Adju-Phos | 0 | 40 | 0 | 0 | 0.00 | 0.00 | 20.00 | 0.00 |
| INI-2002 (10X) + Adju-Phos | 0 | 40 | 0 | 0 | 0.00 | 0.00 | 200.00 | 200.00 |
| INI-4001 + INI-2002 + Adju-Phos | 0 | 440 | 0 | 0 | 200.00 | 0.00 | 20 | 0 |
| INI-4001 + INI-2002 + Adju-Phos (10:10) | 0 | 440 | 0 | 0 | 200.00 | 0.00 | 200 | 200 |
| RBD + INI-4001 + Adju-Phos | 0 | 440 | 20 | 20 | 200.00 | 0.00 | 0 | 0 |
| RBD + INI-2002 + Adju-Phos | 0 | 80 | 20 | 20 | 0.00 | 0.00 | 20.00 | 0.00 |
| RBD + INI-2002 (10X) + Adju-Phos | 0 | 80 | 20 | 20 | 0.00 | 0.00 | 200 | 0 |
| RBD + INI-4001 + INI-2002 + Adju-Phos | 0 | 480 | 20 | 20 | 200.00 | 0.00 | 20 | 0 |
| RBD + INI-4001 + INI-2002 (10X) + Adju-Phos | 0 | 480 | 20 | 20 | 200.00 | 0.00 | 200 | 0 |
| Alhydrogel + Adju-Phos | 440 | 40 | 0 | 0 | 0 | 0 | 0 | 0 |
| RBD + Alhydrogel + Adju-Phos | 440 | 40 | 20 | 20 | 0.00 | 0.00 | 0 | 0 |
| INI-4001 + INI-2002 + Alhydogel + Adju-Phos | 440 | 40 | 0 | 0 | 200.00 | 0.00 | 20.00 | 0.00 |
| RBD + INI-4001 + Alhydrogel + Adju-Phos | 400 | 40 | 20 | 20 | 200.00 | 0.00 | 0 | 0 |
| RBD + INI-2002 + Alhydrogel +Adju-Phos | 40 | 40 | 20 | 20 | 0.00 | 0.00 | 20.00 | 0.00 |
| RBD + INI-4001+ INI-2002 + Alhydrogel + Adju-Phos | 440 | 40 | 20 | 20 | 200.00 | 0.00 | 20.00 | 0.00 |