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. 2024 Jan 18;17(1):126. doi: 10.3390/ph17010126

Table 2.

Summary of antioxidative, antiproliferative, and anticancer activities of resveratrol-loaded organic nanoparticles.

Drug Organic Nanoparticle Formulation Target System Major Findings Ref.
RSV Polymeric
micelles 		PC12 cell lines

  • Protect cells against Aβ-induced damage by attenuating oxidative stress and affecting apoptosis without long-term cytotoxicity.

 [163]
RSV Solid lipid nanoparticles (SLN) NCTC2544 cell lines

  • Decreases cell proliferation.

  • High cytostatic effect of SLN–RSV in contrast to free RSV.

 [175]
RSV + QUE Liposomes HDFa cell lines
and CD-1 mice

  • It increases apoptosis and decreases leukocyte infiltration.

 [130]
RSV Lipid-core nanocapsules C6 glioma cell lines and rats implanted with C6 glioma cells

  • Tumor size decreases compared to free RSV.

 [179]
Transferrin-modified PEGylated
liposomes 		Xenograft mouse model of GBM
and U-87 MG cell lines

  • Induce a high level of apoptosis and cytotoxicity compared to free RSV.

  • Tumor growth inhibition and increased survival rate in mice.

 [131]
Transferrin (Tf) modified poly ethylene glycol-poly lactic acid (PEG-PLA) nanoparticles C6, U87 cell lines and brain-glioma-bearing rat model

  • Cytotoxicity in C6 and U87 cells was higher than that of free RSV.

  • Tumor volume decreases compared to free RSV.

 [159]
Folate-modified nanostructured lipid carriers MCF-7 cell lines and female Wistar rats

  • High antitumor effect of folate-modified NLCs (RSV-FA-NLCs).

 [138]
PTX and RSV PEGylated liposome MCF-7 cell lines and BALB/c nude mice

  • Increase the bioavailability of the drugs in vivo.

  • Liposome exhibits potent cytotoxicity against the drug-resistant MCF-7/ADR tumor cells.

  • Liposomes improve the bioavailability of the drugs and enhance drug retention in the tumor.

 [133]
EXM/RSV Zein nano-capsules MCF-7, 4T1 cell lines, and female Sprague Dawley rats

  • Increased antitumor activity in cell lines.

  • Reduced tumor volume in mice by 2.4-fold compared to free RSV.

 [162]
RSV Solid lipid nanoparticles SKBR3/PR, SKBR3/PR xenograft tumor
models

  • More apoptosis of cancer cells.

  • Inhibit cell migration compared with free RSV.

 [136]
RSV Dequalinium polyethylene glycol-distearoyl
Phosphatidyl
ethanolamine 		Xenografted resistant A549/cDDP nude mice

  • Cellular uptake is enhanced with induced apoptosis of non-resistant and resistant cancer cells.

 [132]
RSV + CUR Liposomes PTEN-CaP8 cancer cell lines and B6C3F1/J mice

  • Inhibit cell growth and induce apoptosis.

  • Decrease prostatic adenocarcinoma in vivo.

 [96]
RSV Poly(epsilon-caprolactone) (PCL) and poly (d,l-lactic-co-glycolic acid)-poly(ethylene glycol) conjugate (PLGA-PEG-COOH) DU-145, PC-3, and LNCaP cell lines

  • Increased cytotoxicity compared to that of free RSV.

 [124]
DOX and RSV PLGA nanoparticle BALB/c nude mice and MCF-7/ADR and MDA-MB-231/ADR cell lines

  • Increase cytotoxicity in vitro.

  • Inhibit the DOX-resistant tumor growth in vivo without causing systemic toxicity.

 [151]
RSV PLGA-polyethylene glycol (PEG) NPs coated with chitosan Athymic mice

  • Increases bioavailability and reduces tumor growth compared to free RSV.

 [152]
RSV Biomimetic nanocarrier HT29 and HCT116 cell lines and C57/BL6j
female nude
mice

  • Extended circulation effect.

  • A significant antitumor efficacy was observed in vivo.

 [154]
RSV Epidermal growth factor (EGF) conjugated lipid–polymer hybrid nanoparticles HCC827, NCIH2135, and HUVEC cell lines and
BALB/c nude mice

  • High tumor inhibition and less organ toxicity.

 [176]