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. 2023 Dec 22;16(1):26. doi: 10.3390/v16010026

Figure 3.

Figure 3

The isoleucine to serine substitution in the gH TMD is sufficient for efficient gL-independent membrane fusion. Plasmids encoding gB Ka, gD Ka, gH Ka, gH V99 or gH carrying only one substitution were cotransfected into RK13 cells either in presence or absence of pcDNA-gL and syncytia were measured 19 h post transfection. Shown are mean results of three independent assays with the corresponding standard deviation with values for assays with gB Ka, gH Ka, gD and gL set as 100%. Two-tailed Welch’s t test; ns, not significant; *, p < 0.05; **, p < 0.01; ****, p < 0.0001.