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. 2024 Jan 27;14(1):e1556. doi: 10.1002/ctm2.1556

FIGURE 2.

FIGURE 2

Predisposition of HPV Integration on the Host genome. (A) Assessment of HPV integration sites in distinct regions of the human genome. Comparison between expected (green bar, assuming uniform, random distribution) and the observed (actual numbers, red bar) numbers of HPV integrations. TSS, transcription start site; TTS, transcription termination region; UTR, untranslated regions. (B) Analysis of HPV integration sites across human chromosomes. Observed integration site counts (red bars) are compared with expected counts (blue bars), assuming uniform, random distribution. (C) Evaluation of viral breakpoints within fragile sites on human genome. Observed integration site counts (red bars) are compared with expected counts (blue bars, assuming uniform, random distribution). (D) Assessment of HPV integration sites within specific fragile sites. Comparison the expected (green bar, uniform, random distribution,) and observed (red bar) HPV integration counts. p Values were calculated using the Chi‐square test. ‘*’ indicates p < .05. ‘**’ indicated p < .01.