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. 2024 Jan 5;12(1):112. doi: 10.3390/microorganisms12010112

Table 2.

Reported inhibitor values for the G6PD::6PGL enzymes of the parasites: P. falciparum, P. vivax, G. lamblia, T. vaginalis.

Enzyme Inhibitor IC50
(µM)		 k2
(M−1S−1)		 Type Inhibition Culture IC50
(µM)		 Reference
PfGluPho C276-1187 127 ND G6P: NC; NADP+ : NC ND [37,104]
CB22 4.6 ND G6P: NC; NADP+ : NC ND [107]
CB61 5.1 ND G6P: MT; NADP+ : NC ND [107]
CB62 11.6 ND ND ND [107]
CB63 1.7 ND G6P: M; NADP+ : NC ND [107]
CB64 19.9 ND ND ND [107]
CB70 4.5 ND G6P: MT; NADP+ : NC ND [107]
CB103 1.1 ND G6P: MT; NADP+ : NC ND [107]
CB104 7.6 ND G6P: MT; NADP+ : NC ND [108]
ML276 0.889 ND ND 2.6 [108]
ML304 0.190 ND G6P: C; NADP+ : MT 0.190 [111]
Ellagic acid 0.076 ND G6P: MT; NADP+ : MT 0.105 [110]
21 (vz0527) 1.72 ND ND ND [109]
4 (vz1732) 0.9 ND G6P: NC; NADP+ : NC ND [109]
SBI-0797750 0.0067 ND G6P: C; NADP+ : MT 0.073 [112]
PvGluPho Ellagic acid 0.032 ND G6P: MT; NADP+ : MT ND [109]
ML304 15.3 ND G6P: C; NADP+ : MT ND [109]
21 (vz0527) 0.2 ND ND ND [109]
4 (vz1732) 0.2 ND ND ND [109]
SBI-0797750 31 ND G6P: MT; NADP+ : MT ND [112]
GlG6PD::6PGL H-BZM-2 37 2.3 ND 36 [113]
O2N-BZM-7 12 1.92 ND 14 [113]
O2N-BZM-9 20 6.13 ND 17 [113]
CNZ-7 150 0.97 ND 8.7 [114]
CNZ-8 80 0.60 ND 15 [114]
CMC-1 70 1.88 ND 15 [114]
FLP-2 256 0.82 ND 24.1 [114]
TvG6PD::6PGL O2N-BZM-7 22 0.8 ND 6 [113]
O2N-BZM-9 240 1.6 ND 4 [113]
CNZ-3 93 0.66 G6P: NC; NADP+ : C ND [115]
CNZ-17 356 0.38 G6P: UC; NADP+ : UC ND [115]
JMM-3 155 0.33 G6P: UC; NADP+ : UC ND [115]
MCC-7 260 0.26 G6P: NC; NADP+ : UC ND [115]

ND: Non determinate. C: Competitive-type inhibition. MT: Mixed-type inhibition. NC: Noncompetitive-type inhibition. UC: Uncompetitive-type inhibition.