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. 1998 May;66(5):2290–2299. doi: 10.1128/iai.66.5.2290-2299.1998

FIG. 3.

FIG. 3

FIG. 3

Transmission electron micrographs of R. rickettsii-infected HUVEC from a culture at 72 h postinfection. (a) Cells in the absence of α-lipoic acid. Extensive dilatation of membranes of the endoplasmic reticulum and intracellular rickettsiae are demonstrated (bar, 2 μm). (b) Cells grown in medium supplemented with 100 μM α-lipoic acid (bar, 2 μm). (c) Demonstration of differences in membrane compartments of infected endothelial cells grown without α-lipoic acid (left; bar, 1 μm) and in the presence of 100 μM α-lipoic acid (right; bar, 0.5 μm). (d) Demonstration of intracytoplasmic and intranuclear R. rickettsii in an endothelial cell grown in the presence of 100 μM α-lipoic acid (bar, 5 μm). Abbreviations: R, rickettsiae; ER, endoplasmic reticulum; ONE, outer nuclear envelope.