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Pharmacokinetic parameters of milnacipran in the brain after IP and IV administration at 30 mg/kg in adult male mice.
| Pharmacokinetic Parameters (Brain) |
IP Route | IP Route with Vascular Correction |
IV Route | IV Route with Vascular Correction |
|---|---|---|---|---|
| Cmax (µg/g) * | 0.84 ± 0.11 | 0.79 ± 0.1 | 0.77 ± 0.1 | 0.73 ± 0.1 |
| Tmax (min) | 60 | 60 | 60 | 60 |
| AUC0-3 (µg.min/g) * | 113 ± 6 | 107 ± 6 | 109 ± 5 | 104 ± 5 |
* mean ± SE are shown.
