Table 1.
Description and characterization results of the INI-4001/A-SNP formulations.
| Formulation | A-SNP Conc. (mg/mL) | INI-4001 Conc. (µM) | INI-4001-Coating Density nmol/cm2 |
TEM Size (nm) a | Z-Average Diameter (nm) | PDI | Zeta Potential (mV) b | pH |
|---|---|---|---|---|---|---|---|---|
| A-SNP-50 | 10.0 | --- | --- | 48.9 ± 2.5 | 215 | 0.270 | 46.7 ± 5.4 | 5.9 |
| A-SNP-200 | 40.0 | --- | --- | 199.6 ± 15.3 | 997 | 0.422 | 61.5 ± 4.9 | 6.1 |
| INI-4001 aqueous control | NA | 226.3 | --- | --- | 73 | 0.163 | −62.2 ± 6.8 | 8.2 |
| INI-4001/A-SNP-50 high | 1.0 | 221.2 | 0.20 | 55.9 ± 2.9 | 246 | 0.256 | −20.1 ± 6.2 | 6.2 |
| INI-4001/A-SNP-50 low | 10.0 | 259.8 | 0.02 | 48.3 ± 2.4 | 1107 | 0.334 | 26.6 ± 4.8 | 5.8 |
| INI-4001/A-SNP-200 high | 4.0 | 277.6 | 0.21 | 209.3 ± 10.0 | 631 | 0.249 | −34.1 ± 5.4 | 6.0 |
| INI-4001/A-SNP-200 low | 40.0 | 242.6 | 0.02 | 209.8 ± 18.3 | 1305 | 0.608 | 47.0 ± 3.9 | 6.0 |
a Means ± SEM (n = 21). b Means ± SEM of 3 measurements.