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Effect of INI-4001-coating density and A-SNP size on IFN-α and TNF-α induction of EC-50 in hPBMCs. EC-50 (µM) is shown as mean ± SEM of 3 independent experiments. * Denotes p < 0.05 by Student’s t test versus INI-4001/A-SNP high.
| 50 nm INI-4001/A-SNP | 200 nm INI-4001/A-SNP | ||||
|---|---|---|---|---|---|
| Cytokine | Low | High | Low | High | Aqueous INI-4001 |
| IFN-α | 3.2 ± 0.7 | 40.2 ± 30.9 | 13.6 ± 7.6 | 15.0 ± 8.8 | 34.0 ± 10.3 |
| TNF-α | 4.6 ± 1.5 * | 132.1 ± 67.2 | 1.6 ± 0.8 * | 14.5 ± 5.6 | 21.4 ± 8.7 |
