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. 2023 Dec 29;13(1):35. doi: 10.3390/pathogens13010035

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Structure and genomic organization of influenza A virus. The virion (A) consists of 8 negative sense ssRNA segments complexed with the nucleoprotein (NP, not pictured) to form the helical ribonucleoprotein (RNP). Each segment is associated with an RNA-dependent RNA polymerase (RdRP) complex composed of basic protein 1 (PB1), basic protein 2 (PB2), and the acidic protein (PA). Envelope-associated proteins include hemagglutinin (HA), neuraminidase (NA), matrix protein (M1), and the integral membrane protein (M2). Genomic segments 1–7 encode for one of these structural proteins and the 8th segment encodes for nonstructural proteins (NS) (B). Image (A) created with BioRender.com.