Figure 5.

Maternal fructose intake influences placental molecules related to preeclampsia of their descendants. Placental levels of specific mRNA for (A) sFLT-1, (B) ENG, (C) PTN, and (D) PGF, and plasma levels of (E) sFLT-1 and (F) PGF. Placental (mRNA) expression and preeclampsia molecules levels from control mothers (CC, empty bar), or pregnant rats from fructose-fed mothers subjected (FF, black bar) or not (FC, grey bar) to fructose intake throughout pregnancy. Data are expressed as means ± S.E., n = 5 rats. Values not sharing a common letter are significantly different (p < 0.05). Relative target gene mRNA levels were measured by real-time PCR as explained in Materials and Methods, normalized to Rps29 levels and expressed in arbitrary units (a.u.). Data are expressed as means ± S.E., n = 5 (CC); 4 (FC); and 5 (FF) rats. Values not sharing a common letter are significantly different (p < 0.05). PTN: pleiotrophin; ENG: endoglin; PGF: placental growth factor; sFLT-1: soluble Fms-related receptor tyrosine kinase 1.