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. 2024 Jan 7;16(1):30. doi: 10.3390/toxins16010030

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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aboBoNT-A directly inhibited mechanosensitive firing. (A) A representative trace showing the response of afferent nerves to distension prior to (control) and 90 min after application of 100 U/mL aboBoNT-A. (B) Afferent responses to distension were significantly reduced in preparations that received intravesical aboBoNT-A (n = 9) compared to vehicle-treated (n = 13) preparations (p < 0.0001; two-way ANOVA). (C) Percentage change in peak firing at 15 and 50 mmHg showed no difference between the early and later time points (p = 0.1003; n = 9; two-way ANOVA). (D) The pressure–volume relationship was significantly lower in preparations that received intravesical aboBoNT-A (n = 9) than in vehicle-treated (n = 13) preparations (**** = p < 0.0001; two-way ANOVA).