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. 2024 Jan 7;16(1):30. doi: 10.3390/toxins16010030

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The effect of active (LC/A) and inactive (LC/A (0)) light chains on distension-induced afferent signalling. (A) A representative trace showing the response of afferent nerves to distension prior to (control) and 90 min after rLC/A treatment. (B) A representative trace showing the response of afferent nerves to distension prior to (control) and 90 min after rLC/A (0) treatment. (C) Distension-induced afferent responses were significantly reduced by rLC/A (**** p < 0.0001; n = 5; two-way ANOVA) and rLC/A (0) (**** p < 0.0001; n = 5; two-way ANOVA). The distension-induced firing in preparations treated with rLC/A (0) was significantly lower than in those treated with rLC/A (**** p < 0.0001 two-way ANOVA). (D) The pressure–volume relationship of rLC/A-treated preparations was significantly lower than that of vehicle-treated preparations (**** p < 0.0001; n = 5; two-way ANOVA), while rLC/A (0) was not significantly different (p = 0.065; n = 5; two-way ANOVA) (** p < 0.01; *** p < 0.001).