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. 2024 Jan 7;16(1):30. doi: 10.3390/toxins16010030

Figure 8.

Figure 8

The effect of L-NAME pre-treatment on the inhibitory effect of rBoNT/A (0). (A) L-NAME treatment alone did not alter distension-induced afferent firing, as the response to intravesical L-NAME was not different to that of control (p = 0.475; n = 5; two-way ANOVA). (B) Afferent responses to distension of the bladder following treatment with L-NAME alongside rBoNT/A (0) were not different to the afferent response to controlled distension of the bladder (p = 0.3881; n = 5; two-way ANOVA). (C) The pressure–volume relationship was not altered by intravesical L-NAME alone (p = 0.475; n = 5; two-way ANOVA). (D) The pressure–volume relationship was significantly increased following treatment with L-NAME alongside rBoNT/A (0) compared to control responses (**** p < 0.0001; n = 5; two-way ANOVA). Sidak’s multiple comparisons test revealed significant increases in volume from 10 mmHg (**** p < 0.0001) to 50 mmHg (**** p < 0.0001).