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. 2024 Jan 7;16(1):30. doi: 10.3390/toxins16010030

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The effect of TNP-ATP pretreatment on the inhibitory effect of rBoNT/A (0). (A) The afferent response to intravesical TNP-ATP was not different to that of control (p = 0.4396; n = 6; two-way ANOVA). (B) The afferent response to distension following TNP-ATP applied alongside rBoNT/A (0) was significantly lower than that of control (* p = 0.0301; n = 6; two-way ANOVA). (C) The pressure–volume relationship was not altered by intravesical TNP-ATP alone (p = 0.2868; n = 6; two-way ANOVA). (D) The pressure–volume relationship was significantly increased by TNP-ATP applied alongside rBoNT/A (0) (**** p < 0.0001; n = 6; two-way ANOVA).